Catalog number:
SPC-982D-RPE
Name:
Rabbit Anti-Human FGFR2 (pTyr656 + pTyr657) Polyclonal: RPE
Size:
100 µl
Supplier:
StressMark antibodies
Price:
394.00
Immunogen:
A phospho-specific peptide corresponding to residues surrounding Tyr656 and Tyr657 of human FGFR2 (AA653-659)
Antibody's target:
Human FGFR2 (pTyr656 + pTyr657)
Antibody's full description:
Rabbit Anti-Human FGFR2 (pTyr656 + pTyr657) Polyclonal
Antibody's category:
Polyclonal Antibodies
Antibody's other name:
bacteria-expressed kinase Antibody, BBDS Antibody, FGFR2 Antibody, BEK Antibody, BEK fibroblast growth factor receptor Antibody, BFR1 Antibody, CD332 Antibody, CD332 antigen Antibody, CEK3 Antibody, CFD1 Antibody, Craniofacial dysostosis 1 Antibody, ECT1 Antibody, FGF receptor Antibody, Fibroblast growth factor receptor 2 Antibody, Hydroxyaryl protein kinase Antibody, Jackson Weiss syndrome Antibody, JWS Antibody, K SAM Antibody, K-sam Antibody, Keratinocyte growth factor receptor 2 Antibody, Keratinocyte growth factor receptor Antibody, KGFR Antibody, KSAM Antibody, protein tyrosine kinase, receptor like 14 Antibody, soluble FGFR4 variant 4 Antibody, TK14 Antibody, TK25 Antibody
Verified applications:
WB, AM
Raised in:
Rabbit
Antibody's reactivity:
Human
Antibody's recommended dilutions for use:
WB (1:250); optimal dilutions for assays should be determined by the user.
Antibody's purified from:
Peptide Affinity Purified
Recommended buffer for storage:
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Antibody's concentration:
See included datasheet or contact our support service
Antibody's specificity:
Detects 92.025 kDa.
Storage recommendations:
-20°C
Shipping recommendations:
Blue Ice or 4°C
Certificate of analysis:
A 1:250 dilution of SPC-982 was sufficient for detection of FGFR2 (pTyr656 + pTyr657) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody in cell:
Cell Membrane, Golgi Apparatus, Cytoplasmic Vesicle
Tissue specificity:
See included datasheet or contact our support service.
Scientific context:
FGFR2 plays an important role in regulation of cell differentiation, proliferation, migration and apoptosis. It is involved in differentiation and proliferation of osteoblasts and keratinocytes; activates several signalling cascades, such as the MAPK and AKT1 pathway. Missense mutations are associated with ligand independent activation of TK25 (FGFR2) or an activating autocrine signalling loop. Mutations and gene amplifications are involved in various human cancers, and overexpression has been associated with tumourigenesis. Certain missense mutations have been associated with breast, ovarian, endometrial, prostate, bladder, gastric and lung cancers.
Bibliography:
Refer to PubMed
Released date:
29/Aug/2016
NCBI number:
NP_000132
Gene number:
2263
Protein number:
P21802
PubMed number:
Refer to PubMed
Tested applications:
To be tested
Tested reactivity:
To be tested
Antibody's datasheet:
Contact our support service to receive datasheet or other technical documentation.
Representative figure link:
No Data Available
Warning information:
Non-hazardous
Country of production:
Canada
Total weight (kg):
1.4
Net weight (g):
0.1
Stock availabilit:
In Stock
Description:
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Test:
StressMark antibodies supplies antibodies that are for research of human proteins.
Properties:
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Group:
Polyclonals and antibodies
About:
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name:
Oryctolagus cuniculus