Catalog number:
SPC-1012D-APC
Name:
Rabbit Anti-Human LYN (pTyr508) Polyclonal: APC
Size:
100 µl
Supplier:
StressMark antibodies
Price:
396.00
Immunogen:
A phospho-specific peptide corresponding to residues surrounding Tyr508 of human Lyn (AA505-511)
Antibody's target:
Human LYN (pTyr508)
Antibody's full description:
Rabbit Anti-Human LYN (pTyr508) Polyclonal
Antibody's category:
Polyclonal Antibodies
Antibody's other name:
AA407514 antibody, Hck 2 antibody, JTK 8 antibody, Lck/Yes related novel protein tyrosine kinase antibody, LYN antibody, LYN_HUMAN antibody, p53Lyn antibody, Tyrosine protein kinase LYN antibody
Verified applications:
WB, AM
Raised in:
Rabbit
Antibody's reactivity:
Human
Antibody's recommended dilutions for use:
WB (1:250); optimal dilutions for assays should be determined by the user.
Antibody's purified from:
Peptide Affinity Purified
Recommended buffer for storage:
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Antibody's concentration:
See included datasheet or contact our support service
Antibody's specificity:
Detects 58.443 kDa.
Storage recommendations:
-20°C
Shipping recommendations:
Blue Ice or 4°C
Certificate of analysis:
A 1:250 dilution of SPC-1012 was sufficient for detection of LYN (pTyr508) in 10 µg of human A431 cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody in cell:
Cell membrane, Nucleus, Cytoplasm
Tissue specificity:
Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.
Scientific context:
LYN is a protein-tyrosine kinase. It is involved in regulation of innate and adaptive immune response, cell degranulation and hematopoiesis. It is also involved in signal transduction induced by growth factors, cytokines and integrin signalling. It also responds to DNA damage and genotoxic agents. Its regulations many aspects of the cell depending on cell type and context. Lyn has been associated with increase in invasiveness and mestasis of breast cancer cells.
Bibliography:
Refer to PubMed
Released date:
29/Aug/2016
NCBI number:
NP_002341
Gene number:
4067
Protein number:
P07948
PubMed number:
Refer to PubMed
Tested applications:
To be tested
Tested reactivity:
To be tested
Antibody's datasheet:
Contact our support service to receive datasheet or other technical documentation.
Representative figure link:
No Data Available
Warning information:
Non-hazardous
Country of production:
Canada
Total weight (kg):
1.4
Net weight (g):
0.1
Stock availabilit:
In Stock
Description:
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Test:
StressMark antibodies supplies antibodies that are for research of human proteins.
Properties:
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Group:
Polyclonals and antibodies
About:
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name:
Oryctolagus cuniculus