Catalog number:
SPC-983D-APC
Name:
Rabbit Anti-Human FGFR2 (pTyr656 + pTyr657) Polyclonal: APC
Size:
100 µl
Supplier:
StressMark antibodies
Price:
396.00
Immunogen:
A phospho-specific peptide corresponding to residues surrounding Tyr647 and Tyr648 of human FGFR3 (AA644-651)
Antibody's target:
Human FGFR2 (pTyr656 + pTyr657)
Antibody's full description:
Rabbit Anti-Human FGFR2 (pTyr656 + pTyr657) Polyclonal
Antibody's category:
Polyclonal Antibodies
Antibody's other name:
ACH Antibody, CD333 Antibody, FGFR3 Antibody, CEK2 Antibody, Fibroblast growth factor receptor 3 Antibody, Heparin binding growth factor receptor Antibody, HSFGFR3EX Antibody, Hydroxyaryl protein kinase Antibody, JTK4 Antibody, MFR 3 Antibody, SAM 3 Antibody, Tyrosine kinase JTK 4 Antibody, Tyrosine kinase JTK4 Antibody, Z FGFR 3 Antibody
Verified applications:
WB, AM
Raised in:
Rabbit
Antibody's reactivity:
Human
Antibody's recommended dilutions for use:
WB (1:250); optimal dilutions for assays should be determined by the user.
Antibody's purified from:
Peptide Affinity Purified
Recommended buffer for storage:
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Antibody's concentration:
See included datasheet or contact our support service
Antibody's specificity:
Detects 87.710 (110-120) kDa.
Storage recommendations:
-20°C
Shipping recommendations:
Blue Ice or 4°C
Certificate of analysis:
A 1:250 dilution of SPC-983 was sufficient for detection of FGFR2 (pTyr656 + pTyr657) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody in cell:
Cell Membrane, Cytoplasmic Vesicle, Endoplasmic Reticulum
Tissue specificity:
Expressed in brain, kidney and testis
Scientific context:
FGFR3 is a receptor-tyrosine kinase that is activated upon binding fibroblast growth factor (FGF). Extracellular ligand binding induces homo- or hetero- dimerization of FGFR to activate signalling. FGFRs have an essential role in regulating cellular differentiation, proliferation and apoptosis. The FGFR3 isoform is specifically involved in chondrocyte development which is physiologically linked to normal skeleton development. Defects in FGFR3 can lead to dwarfism. Overexpressed FGFR3 can promote activation of SHP2 and STAT signalling pathways.Mutations which promote constitutive dimerization of FGFR and kinase activation or impairs internalization and degradation of the receptor have been observed in bladder, skin and oral cancers.
Bibliography:
Refer to PubMed
Released date:
29/Aug/2016
NCBI number:
NP_000133
Gene number:
2261
Protein number:
P22607
PubMed number:
Refer to PubMed
Tested applications:
To be tested
Tested reactivity:
To be tested
Antibody's datasheet:
Contact our support service to receive datasheet or other technical documentation.
Representative figure link:
No Data Available
Warning information:
Non-hazardous
Country of production:
Canada
Total weight (kg):
1.4
Net weight (g):
0.1
Stock availabilit:
In Stock
Description:
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Test:
StressMark antibodies supplies antibodies that are for research of human proteins.
Properties:
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Group:
Polyclonals and antibodies
About:
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
Latin name:
Oryctolagus cuniculus