Rabbit Anti-Human FGFR1 (pTyr653 + pTyr654) Polyclonal: APC
A phospho-specific peptide corresponding to residues surrounding Tyr653 and Tyr654 of human FGFR1 (AA650-657)
Human FGFR1 (pTyr653 + pTyr654)
Antibody's full description:
Rabbit Anti-Human FGFR1 (pTyr653 + pTyr654) Polyclonal
Antibody's other name:
Basic fibroblast growth factor receptor 1 Antibody, bFGF-R-1 Antibody, BFGFR Antibody, FGFR1 Antibody, CD331 Antibody, CEK Antibody, FGFBR Antibody, FGFR1 Antibody, FGFR1/PLAG1 fusion Antibody, fibroblast growth factor receptor 1 Antibody, FLG Antibody, FLT2 Antibody, Fms-like tyrosine kinase 2 Antibody, HBGFR Antibody, heparin-binding growth factor receptor Antibody, HH2 Antibody, HRTFDS Antibody, hydroxyaryl-protein kinase Antibody, KAL2 Antibody, N-SAM Antibody, OGD Antibody, Proto-oncogene c-Fgr Antibody
Antibody's recommended dilutions for use:
WB (1:250); optimal dilutions for assays should be determined by the user.
Antibody's purified from:
Peptide Affinity Purified
Recommended buffer for storage:
PBS pH7.4, 50% glycerol, 0.025% Thimerosal
See included datasheet or contact our support service
Detects 91.868 kDa.
Blue Ice or 4°C
Certificate of analysis:
A 1:250 dilution of SPC-981 was sufficient for detection of FGFR1 (pTyr653 + pTyr654) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Antibody in cell:
Cell Membrane, Nucleus, Cytoplasm, Cytosol, Cytoplasmic Vesicle
Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines.
FGFR1 is a receptor-tyrosine kinase that is activated upon binding fibroblast growth factor (FGF). It is a key player in many numerous cell signalling pathways including MAPK/AKT/PLC/STAT/NF-kB. FGF and the FGFR1 is a stimulator of cell differentiation, proliferation, repair, angiogenesis, pro-survival, anti-apoptosis, etc. Overexpression leads to disregulated cell growth which forms the basis of early oncogenesis. This occurs through amplification, gene duplication, or translocation leading to constitutive activation of the receptor.
Refer to PubMed
Refer to PubMed
To be tested
To be tested
Contact our support service to receive datasheet or other technical documentation.
Representative figure link:
No Data Available
Country of production:
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
StressMark antibodies supplies antibodies that are for research of human proteins.
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.